Views: 0 Author: Site Editor Publish Time: 2025-11-13 Origin: Site
The PFS (Prefilled Syringe) Injection Pen represents a precise and user-friendly solution for delivering injectable medications such as peptides, insulin, and GLP-1 analogs. One of the most important factors in its design and user performance is the filling dose — the total liquid volume preloaded into the syringe. While this may seem like a simple parameter, it significantly affects injection force, duration, and user comfort during actual use.
Most prefilled syringe pens are designed for 1.0 mL or less of liquid medication, depending on the drug concentration and intended therapy regimen.
Typical filling ranges include:
0.5 mL — Often used for high-concentration biologics or single-dose peptide formulations.
0.8 mL – 1.0 mL — The most common range for GLP-1, insulin, and multi-dose prefilled applications.
1.2 mL – 1.5 mL — Used in extended formulations or combination therapies where a larger volume is required per injection.
Each PFS injection pen is carefully calibrated to match its internal drive mechanism with the viscosity and target volume of the drug formulation.
Smaller volumes (≤0.5 mL) generally require lower plunger force and deliver the drug more quickly. The injection process feels smooth and brief, ideal for sensitive users or low-viscosity formulations.
Larger volumes (≥1.0 mL) increase fluid resistance and may require higher force or a slightly longer injection time. For viscous peptide or biologic drugs, pens often integrate spring-assisted drive systems to maintain consistent injection pressure.
For 0.5 mL doses, injection time typically ranges between 2–3 seconds.
For 1.0 mL doses, the duration extends to 5–8 seconds, depending on formulation thickness and needle gauge.
Longer injections are designed to ensure controlled delivery, minimizing tissue irritation and leakage at the injection site.
Lower doses create a lighter tactile sensation with minimal pressure buildup under the skin.
Higher doses produce a more noticeable fullness or warmth due to fluid dispersion in subcutaneous tissue — a normal physiological effect.
Advanced pens regulate delivery speed to optimize comfort and consistency across varying doses.
To maintain accurate delivery across dose variations, PFS injection pens undergo precise mechanical calibration:
Drive force compensation: Adjusting the spring torque or thread pitch to balance higher viscosity or volume.
Needle optimization: Using thinner or shorter needles for smaller doses; reinforced stainless-steel cannulas for higher-volume injections.
Stopper and lubricant selection: Tailored to minimize friction and ensure consistent plunger travel from start to finish.
These factors ensure that, whether the syringe contains 0.5 mL or 1.0 mL, the injection experience remains stable, controlled, and comfortable.
Different dose volumes directly influence treatment adherence and patient satisfaction. Short, comfortable injections encourage regular use, while pens designed for larger, slower injections prioritize accuracy and safety over speed.
For pharmaceutical partners, understanding these differences allows for better drug-device pairing, ensuring each formulation is matched with an optimal injection system.
In PFS injection pen systems, dose volume is more than a filling parameter — it defines the injection dynamics, user comfort, and mechanical behavior of the device.
Whether delivering a micro-dose peptide or a full 1 mL GLP-1 formulation, Sunrise Medical’s precision-engineered pens are designed to maintain stable injection performance, precise dosing, and smooth delivery, ensuring reliability across every therapy application.
